1. Propanoyllysergic acid diethylamide (1P-LSD) was introduced as an uncontrolled alternative to LSD just a few years ago. While evidence is emerging from animal and in vitro studies that 1P LSD could serve as a predrug to LSD but a similar assessment in humans isn’t available. Self-administrations controlled by intravenous and oral administration of 100 mg 1P-LSD-hemitartrate recorded in two participants, followed by analysis of serum and urine samples with a fully validated LC/MS method. Psychometric tests included assessments of a selection of subjective effects as well as administration of the Five Dimensions of Altered States of Consciousness scale (5D-ASC).
In both urine and serum oral administrations of 1P LSD did not result in the detection of LSD which is biphasic elimination and has the terminal elimination half-life of about. 1.5 – 1.5 = 6.4 hours. 1P-LSD was detectable for up to 4.16 hours in serum and 2.7 hours in urine following the administration of intravenous fluids, while LSD was present throughout the serum sample (last sampling was after approx. 24 hours) and as long as 80 hours in urine.
LSD demonstrated first order elimination kinetics, with an approximate. time of 1.5 = 5.7 hours, while 1P-LSD had a rapid decline in concentration in the first hour, followed by a gradual decline, possibly caused by hydrolysis. Its bioavailability LSD after the oral intake of 1P-LSD was nearly 100 percent. The psychosensory effects induced by 1P-LSD and their duration were similar to the ones observed following the ingestion of LSD in other studies , which confirms the hypothesis of a prodrug. The scores of 5D-ASC were higher after oral administration compared to intravenous administration of 1P LSD.
