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Oxazepam 50mg Tablets (+VIP Membership)


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It is a slow-onset, intermediate-acting benzodiazepine. It is often prescribed for anxiety disorders that cause tension, irritability and agitation. It can also be used to treat withdrawal from drugs and alcohol, as well as anxiety related to depression. Oxazepam may be used by doctors for social anxiety, post-traumatic stress disorder (PTSD), insomnia, premenstrual syndrome and other conditions.

Side effects of oxazepam can be similar to other benzodiazepines. They may include headaches, dizziness and drowsiness as well as memory impairment and paradoxical excitement.

The U.S. Food and Drug Administration (FDA), required that the boxed warning for all benzodiazepine medications be updated in September 2020 to clearly describe the risks associated with abuse, misuse, addiction, withdrawal reactions, and physical dependence across all medicines in the class.

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5-9 5%  2,84
10-24 10%  2,69
25-49 15%  2,54
50-99 20%  2,39
100-299 30%  2,09
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Oxazepam

Also known as Serax Ceresta is a short-to-intermediate-acting benzodiazepine. Oxazepam can be used to treat anxiety.as well as in controlling symptoms of alcohol withdrawal syndrome.

It is a metabolite from temazepam and diazepam and has moderate anxiolytic and anticonvulsant properties. It was first patented in 1962, and it was approved for medical use by the FDA in 1964. 

Uses for medical purposes
It is a slow-onset, intermediate-acting benzodiazepine. It is often prescribed for people who have difficulty falling asleep or staying asleep. It is often prescribed for anxiety disorders that are associated with tension, irritability and agitation. It can also be used to treat withdrawal from drugs and alcohol, as well as anxiety related to depression. Oxazepam may be used by doctors for social anxiety, post-traumatic stress disorder (PTSD), insomnia, premenstrual syndrome and other conditions.

Side effects
Side effects of oxazepam can be similar to other benzodiazepines. They include headaches, dizziness and drowsiness as well as memory impairment and paradoxical excitement. However, transient global amnesia is not affected. Side effects of abrupt withdrawal or rapid reduction in dosage may include convulsions, depression and inability to fall asleep.

Interactions
Oxazepam being an active metabolite diazepam means that there is a possibility of interactions with other drugs and food. The exception is the pharmacokinetic CYP450 interactions, e.g. With cimetidine. When taking oxazepam or other benzodiazepines in combination with antidepressant medication (SSRIs like fluoxetine, sertraline and paroxetine or multiple reuptake inhibitors such as bupropion or duloxetine or venlafaxine), or potent painkillers such as opioids (e.g. oxycodone, methadone or morphine. These medicines, as well as other benzodiazepines, can interact in ways that are difficult to predict. It is not recommended to drink alcohol while taking oxazepam. Drinking alcohol and oxazepam together can cause increased sedation, coordination problems (ataxia), decreased muscle tone and, in extreme cases and predisposed patients, life-threatening intoxications such as respiratory depression, coma and collapse. When oxazepam and quetiapine are combined, there is a possibility of blood circulation collapse. This could be the same as blood circulation syncope.

Pharmacology
Oxazepam, an intermediate-acting benzodiazepine in the 3-hydroxy family, acts on benzodiazepine receivers. This increases the effect of GABA to GABAA receptors which causes inhibitory effects on central nervous system.Oxazepam has a half-life between 6 and 9 hours.It has been proven to reduce cortisol levels. According to a British study, Oxazepam absorbs slowly and has the slowest onset time of action among all the benzodiazepines.

Oxazepam is an oxidized active metabolite that forms from the diazepam and nordazepam metabolites. Because it doesn’t require hepatic oxygenation, it can be safer than other benzodiazepines for patients with impaired liver function. Instead, it is simply metabolized through glucuronidation. This means that oxazepam is less susceptible to accumulating and causing adverse reactions in elderly people or those with liver disease. In this regard, oxazepam is very similar to lorazepam. Some organs are more prone to storing oxazepam than others, including the heart and brain of the neonate. The neonate is more susceptible to oxazepam absorption than any other route. It is best to stop taking oxazepam while pregnant and breastfeeding, since oxazepam can be excreted in breastmilk.

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