1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is known as a novel psychedelic substance of the lysergamide class. 1P-LSD is closely related to LSD and is also reported to generate near-identical effects. Because of its originality, little is well-known about the pharmacology of 1P-LSD, but it is believed to produce the effects by holding to serotonin pain in the human brain.
The original synthesis time of 1P-LSD is usually unknown. Unlike most research chemicals, 1P-LSD has no documented record in the research books before its beginning within the online analysis chemical market in 2015. It was marketed being a legal alternative to LSD alongside other story lysergamides like ALD-52, ETH-LAD, and AL-LAD.
Subjective effects contain geometric visual hallucinations, time distortion, improved introspection, conceptual considering, euphoria, and ego loss. User information indicates that the subjective effects of 1P-LSD are really similar to the people of LSD. 1P-LSD is usually made the theory to act as a prodrug for LSD. This kind of speculation is supported by the results of research, showing 1P-LSD is metabolized to LSD in mice. This predicts a near-identical effect account, likely differing primarily in its level of absorption and duration. Its time-honoured psychedelic effects and favourable tolerability has led it to get popular between novel psychoactive material users who use it interchangeably with LSD.
1P-LSD is a semisynthetic chemical substance of the lysergamide friends and family. It truly is related to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl involves the carbonyl chain CH3CH2CO- guaranteed to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group sure at the same location. The composition of 1P-LSD contains a polycyclic group having a bicyclic hexahydro indole bound to a bicyclic quinoline group. For carbon almost eight of the quinoline, a great N, N-diethyl carboxamide is certain.
Centred on their structural similarity to LSD, 1P-LSD likely provides for a partial agonist on the 5-HT2A radio. The psychedelic effects are thought to mainly come from its efficacy on the 5-HT2A receptors distributed throughout the brain. 1P-LSD also most likely displays binding activity at a variety of monoamine receptors, such since those for dopamine and norepinephrine. Nevertheless, there is certainly at present no data to back up these claims.
It has been theorized that 1P-LSD may act because a prodrug to get LSD. While 1P-LSD shows only 38% the potency of LSD in rodents, LSD is definitely discovered via LC-MS when 1P-LSD is usually incubated in human being serum. Follow-up research is being carried out to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, also to decide whether 1P-LSD is definitely hydrolyzed to LSD in palpitating. Or else, it is also possible that 1P-LSD might be able of exerting the personal psychedelic impact.