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Lysergamides, which are polycyclicamides, have tryptamine and phenethylamine groups embedded in their structure. They also have a carboxamide attached to carbon number 8. There are many drugs that have psychedelic effects, including prescription drugs to treat headaches or induce labor. It is possible to alter the substituent attached to nitrogen atoms. Hydroxylation is one way to metabolize lysergamides in humans. It produces compounds that are more attractive to dopamine receptors.
Lysergamides’ psychedelic properties are thought to be due to their partial agonist activity at the 5-HT2A receptor. Lysergamides have a greater affinity for many receptors than other psychedelic drugs.
The role of these interactions in the psychedelic experience remains elusive.